Postmenopausal complete hydatidiform mole: A case report

Complete hydatidiform mole (CHM) cases occurring in the postmenopausal period are quite rare and may be delayed in diagnosis. In the present study, the case reported is of a 55-year-old postmenopausal woman (menopausal for 5 years) who presented with painless postmenopausal bleeding in March 2025, ongoing for ~1 month and was diagnosed with CHM. Transvaginal ultrasonography showed endometrial thickness of 28-mm and serum β-human chorionic gonadotropin (β-hCG) level of 187,240 mIU/ml. After ultrasound-guided curettage, the diagnosis of CHM was confirmed in histopathological examination. Since the patient was postmenopausal, laparoscopic hysterectomy and bilateral salpingo-oophorectomy were performed. Postoperative follow-up was performed in accordance with International Federation of Gynecology and Obstetrics (FIGO) guidelines; the protocol used (weekly β-hCG until negative, then monthly for 6 months) is fully consistent with the 2025 FIGO update. By December 2025, the patient had successfully finished the suggested follow-up regimen and was still in total remission with no signs of recurrence. In patients with abnormal uterine bleeding and high β-hCG levels in the postmenopausal period, gestational trophoblastic diseases should be considered in the differential diagnosis. Malignant complications can be prevented with early diagnosis and treatment.