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Related Concept Videos

Chirality in Nature02:30

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid. The...
Chirality02:25

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...

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Updated: May 15, 2026

A Micropatterning Assay for Measuring Cell Chirality
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A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

Chirality-engineered nanomaterials for biomedical applications.

Zhusheng Huang1, Hao Zhou2, Shaoyin Zhang2

  • 1State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, School of Chemistry and Life Sciences, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China; Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China; Department of Chemistry and Chemical Engineering, Huangshan University, Huangshan 245041, Anhui, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

Chiral nanomaterials precisely control biological interactions for advanced therapies. Their unique structures impact drug delivery, immune responses, and overall therapeutic effectiveness and safety.

Keywords:
Chiral nanomaterialsChiralityDrug deliveryImmunomodulationNano-bio interactionsPrecision medicine

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Area of Science:

  • Nanomedicine
  • Biomaterials Science
  • Immunology

Background:

  • Chirality is fundamental to biological recognition and signaling.
  • Integrating chirality into nanomaterials offers novel strategies for modulating nano-bio interactions.
  • Chiral nanostructures are crucial for advancements in drug delivery and immunomodulation.

Purpose of the Study:

  • To review recent progress in the design of chiral nanomaterials.
  • To emphasize the role of enantioselective biomolecular interactions, drug delivery, and immune modulation.
  • To discuss challenges and opportunities for clinical translation.

Main Methods:

  • Literature review of chiral nanomaterial design and applications.
  • Analysis of studies on nanoscale chirality's influence on biological systems.
  • Discussion of emerging evidence in immunology and nanomedicine.

Main Results:

  • Chiral nanostructures significantly influence protein corona formation, cellular uptake, and biodistribution.
  • Nanoscale chirality impacts pharmacokinetics, therapeutic efficacy, and safety profiles.
  • Chiral nanostructures demonstrate potential in modulating innate and adaptive immunity, including immune checkpoint blockade potentiation.

Conclusions:

  • Chiral nanomaterials offer versatile platforms for biomedical applications, particularly in drug delivery and immunotherapy.
  • Further research is needed to address challenges in scalable synthesis, enantiopurity, and comprehensive safety assessments.
  • Understanding mechanistic insights is key for the successful clinical translation of chiral nanomedicines.