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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: May 15, 2026

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Stimulant Medications and Bone Health.

Christine M Swanson1,2, Julie H Wolfe3, Chadi A Calarge4

  • 1Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz, 12801 E. 17th Ave. Mail Stop 8106, Aurora, CO, 80045, USA. Christine.Swanson@CUAnschutz.edu.

Current Osteoporosis Reports
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

Stimulant medications may harm bone health by affecting nutrient intake and the nervous system. However, they reduce fracture risk in younger ADHD patients, though fracture healing may be impaired.

Keywords:
AmphetamineAttention deficit/hyperactivity disorder (ADHD)Bone mineral density (BMD)FractureMethylphenidateStimulant medication

More Related Videos

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Related Experiment Videos

Last Updated: May 15, 2026

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Area of Science:

  • Pharmacology
  • Metabolic Bone Disease
  • Neuroscience

Background:

  • Stimulant medications are increasingly prescribed for attention deficit/hyperactivity disorder (ADHD).
  • Their impact on bone health is a growing concern due to potential effects on nutrient intake and bone metabolism.
  • Understanding these effects is crucial for safe and effective long-term use.

Purpose of the Study:

  • To review the potential impact of stimulant medications on bone health.
  • To increase awareness regarding these effects.
  • To provide guidance for optimizing the safe use of stimulant medications.

Main Methods:

  • Literature review of studies examining stimulant medication effects on bone metabolism, nutrient intake, and fracture risk.
  • Analysis of data on sympathetic nervous system activation and bone regulation.
  • Synthesis of findings on fracture healing and bone mineral density (BMD).

Main Results:

  • Stimulant use can negatively impact bone health via reduced nutrient intake and sympathetic nervous system activation.
  • In individuals under 25 with ADHD, stimulants may decrease fracture risk, possibly by reducing impulsivity and injury.
  • Concerns exist regarding impaired fracture healing with psychostimulant use, necessitating careful management.
  • Increased prescription and non-prescription use of psychostimulants warrants further investigation.

Conclusions:

  • The net effect of stimulants on bone health involves a balance between behavioral benefits and adverse metabolic effects.
  • Future research should focus on psychostimulants' impact on peak bone mass acquisition, long-term BMD stability, and fracture healing.
  • Optimizing stimulant therapy requires monitoring bone health and considering potential risks alongside therapeutic benefits.