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Related Concept Videos

Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

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Related Experiment Video

Updated: May 15, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

Comprehensive Analysis of Core Genes, Key Pathways, and Immune Infiltration in Intervertebral Disc Degeneration Using

Haoju Lo1, Chunhao Tsai2, Tsanwen Huang3

  • 1Department of Orthopedic Surgery, Da-Chien General Hospital, Miaoli, Taiwan. drhaoju@gmail.com.

Iranian Journal of Allergy, Asthma, and Immunology
|May 14, 2026
PubMed
Summary
This summary is machine-generated.

This study identified key molecular mechanisms and immune characteristics of intervertebral disc degeneration (IVDD). Researchers found specific gene expression changes and immune cell alterations, offering potential biomarkers for IVDD.

Keywords:
Bioinformatics analysisGene differential expressionInfiltration of immune cellsIntervertebral disc degenerationInvestigation of drug-gene interactions

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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

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Last Updated: May 15, 2026

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06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Area of Science:

  • Biomedical research
  • Molecular biology
  • Genomics

Background:

  • Intervertebral disc degeneration (IVDD) is a complex condition with poorly understood molecular underpinnings.
  • Identifying key molecular pathways and cellular players is crucial for developing effective treatments.

Purpose of the Study:

  • To integrate and analyze gene expression data to uncover molecular mechanisms of IVDD.
  • To identify hub genes and analyze immune cell infiltration in IVDD.
  • To validate key gene expression changes in a cellular model of IVDD.

Main Methods:

  • Analysis of two gene expression datasets to identify differentially expressed genes (DEGs).
  • Bioinformatic approaches including enrichment analysis, protein-protein interaction network construction, and machine learning algorithms (LASSO, SVM-RFE).
  • Immune infiltration analysis and validation using qPCR and Western blot in an IL-1β-induced nucleus pulposus cell degeneration model.

Main Results:

  • 112 DEGs were identified, enriched in extracellular matrix remodeling, cytoplasmic translation, and PI3K-Akt signaling.
  • 13 hub genes were pinpointed using network and machine learning analyses.
  • Reduced infiltration of suppressor cells and monocytes was observed in IVDD samples.
  • Downregulation of ADM, ITGB5, RTN4, SLPI, and CSNK1E was confirmed in a cellular IVDD model.

Conclusions:

  • This study systematically elucidates molecular networks and immune characteristics associated with IVDD.
  • Identified hub genes and altered immune cell profiles offer potential diagnostic biomarkers.
  • Findings provide novel insights for targeted drug development and therapeutic strategies for IVDD.