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Updated: May 15, 2026

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
Organizing Pleuritis Presenting as Recurrent Lymphocyte Predominant, Exudative Effusion.
Hossny Alaws1, Saurabh Ashok Sujanyal1,2, Bhavya Talwar1,3
1Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Jacksonville, FL, USA.
Cryptogenic fibrosing pleuritis, a rare condition causing pleural thickening, presents diagnostic and treatment challenges. Medical thoracoscopy offers a less invasive approach for diagnosis and management compared to surgery.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Pathology
Background:
- Long-standing pleural effusions can progress to pleural fibrosis, termed cryptogenic fibrosing pleuritis when etiology is unknown.
- This condition involves persistent exudative effusions and progressive pleural thickening, leading to diagnostic and therapeutic challenges.
- Limited case studies exist, lacking established evidence-based management strategies; treatments like glucocorticoids and decortication show variable success.
Purpose of the Study:
- To highlight the diagnostic and therapeutic utility of medical thoracoscopy in managing cryptogenic fibrosing pleuritis.
- To present a case study illustrating a less invasive treatment approach for this rare condition.
Main Methods:
- Case presentation of an older male with recurrent pleural effusion and asbestos exposure.
- Diagnostic workup included repeated thoracenteses, imaging, and medical thoracoscopy with biopsy.
- Therapeutic intervention involved rapid protocol pleurodesis and tunneled pleural catheter placement.
Main Results:
- Histopathology confirmed organizing pleuritis, ruling out malignancy.
- Medical thoracoscopy provided definitive diagnosis and facilitated simultaneous pleurodesis and drainage.
- The combined approach offered a less invasive alternative to surgical decortication.
Conclusions:
- Medical thoracoscopy is valuable for diagnosing and managing cryptogenic fibrosing pleuritis.
- Thoracoscopy combined with pleural drainage strategies presents a less invasive therapeutic option.
- This approach may be suitable for carefully selected patients, offering an alternative to surgical decortication.
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