Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutrophil-Mediated Inflammatory Response to Zinc Bone Implants: A Single-Cell Transcriptomic Landscape.

Advanced healthcare materials·2026
Same author

Impact of field number and monitor units per segment on magnetic resonance-guided hypofractionated stereotactic radiotherapy for brain metastases: plan quality, deliverability, and robustness trade-offs.

Quantitative imaging in medicine and surgery·2026
Same author

A molybdenum-promoted nickel-aluminum alloy catalyst for high-efficient hydrogenation reduction of nitrate to ammonia and nitrogen.

RSC advances·2026
Same author

Triazine and other herbicides in sediments of lower Laurentian Great Lakes - pre- and post-depositional mobility and in-situ degradation.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.

Advanced healthcare materials·2026
Same author

The Proliferation and Adipogenic/Fibrogenic Fate Commitment of FAPs via an Autocrine LAMA2/ITGβ1-FAK Pathway.

Journal of agricultural and food chemistry·2026

Related Experiment Video

Updated: May 15, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Periodontitis and cardiovascular diseases: bridging the gap through mitochondrial dysfunction.

Weiquan Li1, Mingshu Huang1, Dan Lu2,3

  • 1Center of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.

Frontiers in Oral Health
|May 14, 2026
PubMed
Summary

Mitochondrial dysfunction links periodontitis (gum disease) and cardiovascular diseases (CVD). Targeting these shared mitochondrial pathways may offer new treatments for both conditions.

Keywords:
cardiovascular diseasesmitochondrial dysfunctionoxidative stressperiodontitissystemic inflammation

More Related Videos

Robust Mitochondrial Isolation from Rodent Cardiac Tissue
07:03

Robust Mitochondrial Isolation from Rodent Cardiac Tissue

Published on: August 23, 2024

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells
06:15

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

Related Experiment Videos

Last Updated: May 15, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Robust Mitochondrial Isolation from Rodent Cardiac Tissue
07:03

Robust Mitochondrial Isolation from Rodent Cardiac Tissue

Published on: August 23, 2024

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells
06:15

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

Area of Science:

  • Cardiovascular Research
  • Oral Health
  • Mitochondrial Biology

Background:

  • Epidemiological studies show a link between periodontitis and cardiovascular diseases (CVD).
  • Mechanisms beyond systemic inflammation are not fully understood.
  • Mitochondrial dysfunction is a potential shared pathological pathway.

Purpose of the Study:

  • To review evidence linking mitochondrial dysfunction to both periodontitis and CVD.
  • To explore mechanisms by which periodontal issues affect mitochondria and contribute to CVD.
  • To identify potential therapeutic targets within shared mitochondrial pathways.

Main Methods:

  • Literature review of epidemiological and mechanistic studies.
  • Analysis of how dysbiotic oral environments impact mitochondrial function.
  • Examination of mitochondrial dynamics, mitophagy, and biogenesis in disease contexts.

Main Results:

  • Mitochondrial dysfunction, including redox imbalance and impaired quality control, is implicated in both conditions.
  • Abnormal mitochondrial dynamics, mitophagy, and biogenesis are key shared mechanisms.
  • Periodontal inflammation can disrupt mitochondrial functions, exacerbating local and systemic disease.

Conclusions:

  • Mitochondrial dysfunction is a critical link between periodontitis and cardiovascular diseases.
  • Understanding these shared pathways may lead to novel therapeutic strategies.
  • Targeting mitochondrial pathways could simultaneously address periodontitis and CVD.