Related Experiment Video
Updated: May 15, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Type 2 Autoimmune Pancreatitis in a Young Adult Male: A Diagnostic Challenge
Reza Alavi1, Syed Hussaini1, Juan Gonzalez Velazquez1
1Internal Medicine, HCA Florida Bayonet Point Hospital, Hudson, USA.
Abstract:
Type 2 autoimmune pancreatitis (AIP), also known as idiopathic duct-centric pancreatitis, is a rare form of chronic pancreatitis that primarily affects younger individuals and is not associated with IgG4-related disease. Unlike type 1 AIP, serum IgG4 levels are typically normal, making diagnosis challenging and often dependent on a combination of clinical, radiologic, histopathologic, and therapeutic response criteria. We present a 28-year-old male with acute pancreatitis, significant weight loss, and gastrointestinal symptoms. Imaging findings were suggestive of autoimmune pancreatitis. Laboratory evaluation demonstrated elevated total IgG and IgG1 with normal IgG4 levels and a positive anti-smooth muscle antibody. Endoscopic ultrasound-guided pancreatic biopsy revealed nonspecific chronic inflammation and fibrosis, while liver biopsy was consistent with autoimmune hepatitis. In the absence of definitive pancreatic histopathology, the overall clinical presentation was concerning for concomitant type 2 autoimmune pancreatitis.
Related Concept Videos
Type I Diabetes I: Introduction
Chronic Pancreatitis I: Introduction
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Type I Diabetes II: Pathophysiology
Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pancreatitis II: Pathophysiology

