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Updated: May 16, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Diverse Transformations Involving Sulfamoyl Fluorides (RNHSO2F) as Fluorosulfonamide Radical Precursors
Xian Zhang1, Heyin Li1, Zhen Wang1
1State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
None:
Sulfamoyl fluorides play a significant role in click chemistry. Notably, the synthesis of sulfamoyl fluorides via a radical fluorosulfonamidation process has attracted widespread interest. However, the narrow range of radical types has hindered further application of NSO2F radicals. Herein, we report the conversion of sulfamoyl fluorides (RNHSO2F) to fluorosulfonamide radicals under mild conditions; the fluorosulfamide radical serves as a key intermediate, enabling the diverse transformation of this radical species and facilitating the synthesis of various fluorosulfamide derivatives (R1R2NSO2F).
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