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Chiral Analysis for High-Throughput Reaction Screening: Recent Advances in Accelerating Asymmetric Catalysis
1State Key Laboratory of Fluorine and Nitrogen Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 14, 2026
Summary
High-throughput experimentation (HTE) in asymmetric catalysis is slowed by slow enantiomeric excess (ee) analysis. New chiral analytical methods accelerate discovery by enabling faster, more accurate ee determination from complex mixtures.
Area of Science:
- Catalysis
- Analytical Chemistry
- Chemical Engineering
Background:
- High-throughput experimentation (HTE) accelerates discovery in asymmetric catalysis.
- Current limitations in HTE are analytical readouts, specifically determining enantiomeric excess (ee).
- Rapid and reliable ee determination from crude mixtures is a major bottleneck.
Purpose of the Study:
- To review advancements in chiral analytical methodologies for HTE.
- To highlight the impact of these methods on accelerating asymmetric catalysis discovery.
- To address the bottleneck of ee determination in HTE.
Main Methods:
- Serial analysis: Shortens individual measurement times and increases information density.
- Parallel analysis: Multiplexes signals for microplate formats.
- Techniques include chromatography, spectroscopy, mass spectrometry, and nuclear magnetic resonance.
Main Results:
- New chiral analytical methods offer solutions for rapid and reliable ee determination.
- Methods are compatible with multiple substrates and robust against matrix interference.
- These advancements enable earlier evaluation of substrate generality and minimize bias.
Conclusions:
- Advancements in high-throughput chiral analytical methodologies significantly accelerate discovery in asymmetric catalysis.
- These methods generate high-dimensional datasets to guide catalyst and reaction optimization.
- The focus is on developing universally applicable asymmetric transformations.
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