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Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

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Updated: May 16, 2026

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

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Published on: July 19, 2011

Ultrafiltration Rate in Prolonged Intermittent Kidney Replacement Therapy in Critically Ill Patients: A Randomized

Vijay Kalathia1, Snehal Gaikwad1, Vipul Chakurkar1

  • 1Renal Unit, King Edward Memorial Hospital, Pune, India.

Hemodialysis International. International Symposium on Home Hemodialysis
|May 14, 2026
PubMed
Summary

A 4 mL/kg/h ultrafiltration rate reduced hypotension and complications in critically ill patients with acute kidney injury undergoing prolonged intermittent kidney replacement therapy (KRT). This rate is optimal for patient outcomes.

Keywords:
acute kidney injuryhypotensionmortalityprolonged intermittent KRTultrafiltration rate

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Published on: July 19, 2018

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Intensive Care Unit Management

Background:

  • Fluid overload is a key mortality factor in critically ill patients with acute kidney injury.
  • Ultrafiltration during kidney replacement therapy can cause hypotension.
  • Optimal ultrafiltration rates for patients on vasopressors during prolonged intermittent KRT remain unknown.

Purpose of the Study:

  • To determine the optimal ultrafiltration rate for critically ill patients with acute kidney injury undergoing prolonged intermittent KRT.
  • To assess the impact of different ultrafiltration rates on hemodynamic stability and complications.

Main Methods:

  • Randomized controlled trial comparing ultrafiltration rates of 2 mL/kg/h, 4 mL/kg/h, and a control group.
  • Monitored mean arterial pressure, inotrope score, and vasopressor dependency index.
  • Documented episodes of hypotension and premature session termination.

Main Results:

  • The 4 mL/kg/h ultrafiltration rate group showed significantly lower incidence of hypotension and premature session termination.
  • No significant differences in mean arterial pressure or vasopressor dependency index changes were observed between groups.
  • Hypotension was associated with increased 30-day mortality and longer ICU stays.

Conclusions:

  • An ultrafiltration rate of 4 mL/kg/h appears to be optimal for reducing complications in critically ill patients undergoing prolonged intermittent KRT for acute kidney injury.
  • Higher ultrafiltration rates may improve hemodynamic stability without compromising overall hemodynamic parameters.