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Published on: January 7, 2014
FAM30A Induces Inflammation and Oxidative Damage in PDLSCs by Targeting miR-424-5p.
Wang Zhi1, Lina Huang2, Jianan Kang3
1Department of Stomatology, PKUCare Lu'an Hospital, Changzhi, China.
International Dental Journal
|May 14, 2026
Summary
FAM30A is a diagnostic marker and risk factor for chronic periodontitis (CP). It targets miR-424-5p, negatively impacting periodontal ligament stem cells (PDLSCs) function in CP.
Area of Science:
- Oral biology
- Periodontology
- Molecular diagnostics
Background:
- Chronic periodontitis (CP) is a prevalent inflammatory disease affecting periodontal tissues.
- Identifying reliable biomarkers for CP diagnosis and understanding disease mechanisms are crucial.
Purpose of the Study:
- To evaluate the diagnostic utility of FAM30A in chronic periodontitis (CP) patients.
- To elucidate the regulatory role of FAM30A in the pathogenesis of CP.
Main Methods:
- Analysis of FAM30A expression in saliva and periodontal ligament tissues from 104 CP patients.
- In vitro modeling using lipopolysaccharide (LPS)-stimulated periodontal ligament stem cells (PDLSCs).
- Assessment of cell proliferation, apoptosis, inflammation, and oxidative stress markers.
Main Results:
- FAM30A was significantly upregulated in CP patients and served as a diagnostic marker.
- FAM30A expression increased upon LPS stimulation in PDLSCs.
- FAM30A negatively regulates PDLSC function by targeting miR-424-5p, promoting apoptosis and inflammation.
Conclusions:
- FAM30A is a potential diagnostic biomarker and a key regulator in chronic periodontitis.
- Targeting the FAM30A/miR-424-5p axis may offer therapeutic strategies for CP.
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