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Updated: May 16, 2026
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Modified Single-Loop Reconstruction for Pancreaticoduodenectomy
Published on: September 28, 2019
Contemporary short-term post-operative outcomes after resection of entero-pancreatic NETs: a population-based study
Léamarie Meloche-Dumas1, Simron Singh2, Calvin Law3
1Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Summary
Surgery for neuroendocrine tumors (NETs) results in significant morbidity for about a quarter of patients, with mortality under 5%. Most patients recover well at home, highlighting the need for informed patient counseling.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Surgery is a primary treatment for neuroendocrine tumors (NETs), but patient outcomes vary significantly.
- Understanding the real-world morbidity associated with NET surgery is crucial for optimizing patient selection and improving outcomes.
- This study focuses on the short-term outcomes following surgical resection of entero-pancreatic NETs.
Purpose of the Study:
- To evaluate the short-term morbidity and recovery patterns after surgical resection of entero-pancreatic neuroendocrine tumors (NETs).
- To identify factors associated with major morbidity and prolonged recovery after NET surgery.
- To provide data for improved patient counseling and treatment decision-making regarding NET surgery.
Main Methods:
- A population-based retrospective cohort study was conducted using data from 2000-2023.
- Adult patients undergoing surgery for entero-pancreatic NETs were included.
- Outcomes assessed included 90-day major morbidity (Clavien-Dindo grade 3-5) and 90-day days-at-home (DAH-90), with logistic regression analyzing associated factors.
Main Results:
- Of 3699 surgeries, 30.5% involved pancreatic primaries and 58.6% had metastases. Overall 90-day major morbidity was 24.4%, with rates of 26.9% (hepatectomy), 30.3% (pancreatectomy), 21.3% (enterectomy), and 30.4% (combined resection).
- Overall 90-day mortality was 3.4%. Independent predictors of increased 90-day major morbidity included combined resection (OR 1.44), pancreatoduodenectomy (OR 2.35), increasing age (OR 1.21), and higher comorbidity burden (OR 1.56).
- Median DAH-90 was 82 days and was not significantly different by surgery type. Combined hepatectomy, pancreatoduodenectomy, and higher comorbidity were associated with fewer DAH-90.
Conclusions:
- Approximately one in four patients experience significant morbidity within 90 days of surgery for NETs, with mortality rates below 5%.
- The majority of patients spend most of their recovery time at home following NET surgery.
- These findings are essential for accurately counseling patients, guiding treatment discussions, and managing expectations for post-operative recovery.
