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Related Experiment Video

Updated: May 16, 2026

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Tissue rigidity phase transition shapes morphogen gradients.

Camilla Autorino1,2, Diana Khoromskaia3,4,5,6, Louise Harari1

  • 1Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Nature Cell Biology
|May 14, 2026
PubMed
Summary
This summary is machine-generated.

Tissue rigidity transitions dynamically regulate morphogen gradients during development. This process ensures robust cell fate patterning by controlling signal timing and spread, revealing a multiscale regulatory mechanism.

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Last Updated: May 16, 2026

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
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Published on: October 17, 2011

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12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Published on: October 28, 2013

Area of Science:

  • Developmental Biology
  • Biophysics
  • Cell Biology

Background:

  • Cell fate decisions are guided by mechanochemical cues within the microenvironment.
  • How global tissue properties influence these cues during collective cell differentiation is not well understood.

Purpose of the Study:

  • To investigate how tissue-scale rigidity transitions shape morphogen signaling during development.
  • To uncover the regulatory mechanisms linking tissue material properties and developmental patterning.

Main Methods:

  • Rigidity percolation theory
  • Reaction-diffusion modeling
  • Quantitative imaging
  • Optogenetics in zebrafish

Main Results:

  • Tissue rigidity patterns dynamically shape the Nodal morphogen gradient by altering its concentration and signaling speed.
  • Nodal signaling increases cell-cell adhesion, triggering a rigidity transition and tissue reorganization.
  • This reorganization restricts Nodal diffusivity and accelerates Lefty expression, ensuring precise patterning.

Conclusions:

  • A multiscale regulatory mechanism exists where positional information and tissue properties dynamically influence each other.
  • Tissue rigidity transitions are crucial for robust morphogen gradient formation and timely signal termination.
  • This study reveals a self-generated feedback loop controlling developmental patterning.