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The efficiency of 0.01% topical atropine on the myopia prevention in low refractive error population with different

Chia-Yi Lee1,2,3, Shun-Fa Yang1,4, Yu-Ling Chang5

  • 1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

BMC Ophthalmology
|May 14, 2026
PubMed

Insights

Topical atropine (ATR) effectively prevented myopia progression in children with low refractive errors. The 0.01% ATR treatment showed significant reductions in spherical equivalent refraction and axial length changes, particularly in those with initial plus spherical equivalent refraction.

Area of Science:

  • Ophthalmology
  • Pediatric Optometry
  • Myopia Control

Background:

  • Myopia is a growing public health concern, especially in children.
  • Low refractive errors can progress to high myopia if not managed.
  • Topical atropine is explored for its potential in myopia prevention.

Purpose of the Study:

  • To evaluate the efficacy of 0.01% topical atropine (ATR) in preventing myopia.
  • To assess ATR's effect on refractive error and axial length in children with low refractive errors.

Main Methods:

  • Retrospective cohort study involving children with low refractive error.
  • Comparison between a group using 0.01% ATR and a non-ATR control group.
  • Primary outcomes: changes in spherical equivalent refraction (SER) and axial length (AXL) over one year.

Main Results:

  • Significantly lower SER change and AXL elongation in the ATR group versus the non-ATR group (P < 0.001).
  • ATR was more effective in individuals with initial plus SER compared to minus SER (P < 0.05).
  • Outdoor activity inversely correlated with myopia progression in the ATR group (P = 0.006).

Conclusions:

  • 0.01% topical atropine demonstrates potential for myopia prevention in low refractive error populations.
  • The effect is more pronounced in individuals with initial plus SER.
  • Environmental factors like outdoor activity influence myopia progression alongside ATR treatment.
Abstract

Keywords:
AgeAxial lengthDual focus contact lensMyopiaSpherical equivalent refraction

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