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Cerebral Oxygen Saturation During Less-Invasive Surfactant Administration Using a High-Pressure CPAP Respiratory
Jan Trieschmann1, Anika Verhoef1, Angela Kribs1
1Division of Neonatology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Aim:
To describe changes in peripheral oxygen saturation (SpO2) and regional cerebral oxygenation (rcSO2) during less invasive surfactant administration (LISA) in a high-level continuous positive airway pressure (CPAP) respiratory support delivery room protocol in very low birth weight infants (VLBW).
Methods:
This is a secondary analysis of data from the randomized-controlled Extrauterine Placental Transfusion in Resuscitation of VLBW infants (EXPLAIN) trial. In total, 38 patients were included. The pressure and changes in heart rate, SpO2 and rcSO2 were assessed 10 min before until 10 min after the LISA procedure. Basic outcome data for the patient collective were collected.
Results:
Mean gestational age was 27 + 6 weeks (±15 days), and mean birth weight was 995.8 g (±298.8). All infants were eligible for LISA. During LISA, heart rate, SpO2 and rcSO2 decreased significantly (mean change 32.4 (± 27.5) bpm, -14.5 (± 10.7) % and -11.9 (± 9.1) %, respectively; all p < 0.001). Moreover, two infants developed a pneumothorax and three infants required endotracheal intubation within 72 h after birth.
Conclusions:
With the approach of a high-level CPAP setting, we observed transient decreases in heart rate and oxygenation levels during LISA. The magnitude of these decreases was within the expected or potentially favourable range compared with prior studies.
Trial Registration:
ClinicalTrials.gov identifier:NCT03916159.
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