Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated Bioinformatics and Structural Assessment Suggest Doxycycline as a Potential Candidate Targeting MMP7 in Lung Cancer and SSc-Associated ILD.

Omics : a journal of integrative biology·2026
Same author

Immunomodulatory Roles of Probiotics: From Intestinal Barrier Regulation to Clinical Applications.

Current pharmaceutical biotechnology·2026
Same author

Enhanced Hypoglycemic Activity of Metformin with the Reduction of the Particle Size.

Biotechnology and applied biochemistry·2026
Same author

Studies on Oxidative Stability of Vegetable Oil During Frying.

Current medicinal chemistry·2026
Same author

Glycosylation in Cancer Medicines Delivery and Their Patents.

Current drug delivery·2026
Same author

A Smart (Ar-tpy)Cu<sup>I</sup>NO<sub>2</sub> Nanocatalyst for Dual C-N Coupled Reductive Cyclization of Phthaladehyde With Imidates to Furnish Isoindolin-1-Ones.

Chemistry, an Asian journal·2026

Related Experiment Video

Updated: May 16, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Addressing Carbapenem Beta-Lactam Resistance by Nanotechnology.

Moupiya Ghosh1, Bimal Krishna Banik2

  • 1Department of Basic Science & Humanities, Office of the Sustainability. Institute of Engineering and Management (IEM), University of Engineering and Management, Newtown, Kolkata, West Bengal, 700160, India.

Current Medicinal Chemistry
|May 15, 2026
PubMed
Summary

Nanotechnology offers a promising solution to combat rising carbapenem resistance in bacteria. Combining nanoparticles with carbapenem antibiotics enhances their effectiveness and overcomes resistance mechanisms.

Keywords:
Carbapenem; Drug resistance; Nanotechnology; ROS; Drug deliverCarbapenem; Drug resistance; Nanotechnology; ROS; Drug delivery

More Related Videos

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
06:42

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

The Use of a &#946;-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
08:06

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

Related Experiment Videos

Last Updated: May 16, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
06:42

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

The Use of a &#946;-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
08:06

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

Area of Science:

  • Biomedical research
  • Nanotechnology
  • Infectious diseases

Background:

  • Carbapenems are last-resort antibiotics for multidrug-resistant infections.
  • Carbapenem-resistant organisms (CROs) pose a significant global health threat.
  • High treatment failure and mortality rates are associated with CROs like Acinetobacter baumannii and Pseudomonas aeruginosa.

Purpose of the Study:

  • To systematically review the application of carbapenems.
  • To analyze the development and mechanisms of carbapenem resistance.
  • To evaluate nanotechnology-based strategies for overcoming carbapenem resistance.

Main Methods:

  • Systematic literature review (2010-2024).
  • Analysis of carbapenem application and resistance mechanisms.
  • Evaluation of nanotechnology-based solutions for carbapenem resistance.

Main Results:

  • Nanoparticle-carbapenem combinations show enhanced antibacterial activity.
  • Reduced Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values observed.
  • Nanocarriers protect carbapenems from degradation and improve bacterial cell penetration.

Conclusions:

  • Nanotechnology-based carbapenem delivery systems are effective against carbapenem resistance.
  • Nanomaterial-antibiotic combinations offer multi-modal mechanisms to bypass bacterial defenses.
  • This approach enhances antibacterial activity and reduces resistance development.