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Recent Advances in Pectin-Based Materials for Therapeutic Applications: A Review
Mohammed Fareed Felemban1, Amal Adnan Ashour2, Faris J Tayeb3
1Department of Maxillofacial Surgery and Diagnostic Science, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Current Pharmaceutical Design
|May 15, 2026
Summary
Pectin, a natural biopolymer, shows promise for drug delivery and therapeutic applications. Modified pectin enhances drug stability and bioavailability for conditions like cancer and diabetes.
Area of Science:
- Biomaterials Science
- Medicinal Chemistry
- Pharmaceutical Research
Background:
- Pectin, a natural biopolymer, offers solubility, biocompatibility, biodegradability, and gelling properties.
- Its hydrogel-forming ability facilitates controlled release of bioactive compounds for targeted drug delivery.
- Pectin's nontoxic nature is advantageous for pharmaceutical and biomedical applications.
Purpose of the Study:
- To review recent advancements (2021-2025) in pectin-based materials for medicinal chemistry.
- To analyze pectin's properties for designing multifunctional materials, especially for controlled drug delivery.
- To highlight diverse therapeutic activities and biomedical applications of pectin-based systems.
Main Methods:
- Comprehensive literature review of pectin-based materials and their applications.
- Analysis of chemical modifications (esterification, amidation, graft copolymerization) enhancing pectin properties.
- Examination of in vitro and in vivo studies on pectin's therapeutic effects.
Main Results:
- Chemically modified pectin significantly improves physicochemical and functional properties.
- Pectin-based materials enhance drug stability, bioavailability, and site-specific delivery.
- Pectin exhibits intrinsic biological activities including antioxidant, anti-inflammatory, and neuroprotective effects.
Conclusions:
- Pectin is a versatile platform for advanced therapeutic systems and targeted drug delivery.
- Modified pectin facilitates the development of innovative biomedical applications, particularly in anticancer, antidiabetic, and antimicrobial treatments.
- Pectin's inherent biological activities further support its therapeutic potential in medicinal chemistry.
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