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Updated: May 16, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
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Colon cancer versus colitis: a microRNA and gene expression analysis via system biology tools

Fatemeh TajikRostami1, Alireza Omidi Farzin1, Babak Arjmand2,3

  • 1Department of Hematology and Medical Oncology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Gastroenterology and Hepatology From Bed to Bench
|May 15, 2026
PubMed
Abstract

Keywords:
ColitisColon cancerGeneSystem biologymicroRNA

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...