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High Immunohistochemical Expression of Runt-Related Transcription Factor 2 (RUNX2) Is Associated With High Tumor
Siddharth Garg1, Jai K Chaurasia1, Devashish Kaushal2
1Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
High expression of Runt-related transcription factor 2 (RUNX2) in urinary bladder cancer correlates with aggressive tumor features. This finding suggests RUNX2 may serve as a biomarker for predicting progression and developing targeted therapies.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Urinary bladder cancer is a major global health concern with limited validated biomarkers for predicting progression.
- Runt-related transcription factor (RUNX) proteins, including RUNX2, are implicated in cancer development, but their role in bladder cancer is understudied.
Purpose of the Study:
- To investigate the immunohistochemical expression of RUNX2 in urinary bladder cancer.
- To evaluate the association between RUNX2 immunoexpression and clinicopathological parameters.
Main Methods:
- An observational study included 60 histopathologically confirmed urinary bladder carcinoma cases.
- Immunohistochemistry was performed using RUNX2 antibody on archival paraffin-embedded tissues.
- Statistical analysis, including chi-square and Fisher's exact tests, was used to assess correlations.
Main Results:
- High RUNX2 immunoexpression was significantly associated with high tumor grade (p < 0.05).
- Significant associations were found between high RUNX2 expression and muscle invasion, lymph node metastasis, and advanced pTNM stage (p < 0.05).
Conclusions:
- RUNX2 immunoexpression is statistically linked to aggressive features in urinary bladder cancer.
- These findings support RUNX2 as a potential biomarker for guiding treatment and developing targeted therapies for bladder cancer.
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