Related Experiment Video
Updated: May 16, 2026
08:50
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
Pseudo-Progression Observed During Immune Checkpoint Inhibitor Therapy for Advanced Adrenocortical Carcinoma.
Moeto Shimoda1, Shinji Ohtake1,2, Tetsuya Aoki1
1Department of Urology Yokosuka Kyosai Hospital Yokohama Japan.
IJU Case Reports
|May 15, 2026
Summary
Immune checkpoint inhibitors (ICIs) show potential in treating advanced adrenocortical carcinoma (ACC). High tumor mutational burden (TMB) may predict response, but careful monitoring is crucial.
Area of Science:
- Oncology
- Immunotherapy
Background:
- Adrenocortical carcinoma (ACC) is a rare, aggressive cancer.
- Immune checkpoint inhibitors (ICIs) show promise in select ACC cases.
Purpose of the Study:
- To present a case of advanced ACC treated with ICIs.
- To evaluate the role of tumor mutational burden (TMB) and immune RECIST in treatment response.
Main Methods:
- A patient with advanced ACC and pulmonary metastasis received EDP-M chemotherapy followed by pembrolizumab.
- Treatment response was assessed using TMB and immune RECIST criteria.
Main Results:
- The patient had high TMB (27.1/Mb) and showed transient tumor shrinkage despite suspected pseudo-progression.
- The patient ultimately succumbed to liver failure 9 months post-diagnosis.
Conclusions:
- This case suggests a potential therapeutic role for ICIs in adrenocortical carcinoma.
- TMB and immune RECIST are important for evaluating ICI treatment efficacy in ACC.
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