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Related Experiment Video

Updated: May 16, 2026

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

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Published on: March 12, 2018

Cryptococcal Lung Infection Simulating Metastasis in a Myxoid Liposarcoma Patient: A Case Report.

Mariko M Kawamura1,2, Masatake Matsuoka1, Hideki Ujiie3

  • 1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7 Kita-ku, Sapporo, 060-8638, Hokkaido, Japan, hokudai.ac.jp.

Case Reports in Infectious Diseases
|May 15, 2026
PubMed
Summary
This summary is machine-generated.

A rare case of myxoid liposarcoma initially suspected of lung metastasis was correctly diagnosed as pulmonary cryptococcosis after thorough histopathological evaluation. This highlights the importance of fungal infection diagnosis in sarcoma patients to avoid unnecessary treatment.

Keywords:
case reportliposarcomamyxoid liposarcomapulmonary cryptococcosissarcoma

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Published on: August 21, 2012

Area of Science:

  • Oncology
  • Pathology
  • Infectious Diseases

Background:

  • Myxoid liposarcoma is an aggressive soft tissue sarcoma known for lung metastasis.
  • Accurate diagnosis and treatment planning are crucial for improving patient outcomes.

Purpose of the Study:

  • To report a case of myxoid liposarcoma with suspected lung metastasis.
  • To emphasize the importance of histopathological evaluation of lung lesions in sarcoma patients.

Main Methods:

  • A 31-year-old male patient with a thigh mass underwent imaging and biopsy, initially diagnosed as myxoid liposarcoma.
  • Staging scans revealed lung nodules, leading to chemotherapy and surgery.
  • Histopathological examination of lung nodules revealed pulmonary cryptococcosis, not metastasis.

Main Results:

  • Initial diagnosis of Stage IV myxoid liposarcoma was revised to Stage Ib after lung lesions were identified as fungal infections.
  • Patient received neoadjuvant chemotherapy and radiation for the primary tumor.
  • Surgical resection of lung nodules confirmed cryptococcosis, leading to cancellation of further chemotherapy.
  • No recurrence was observed over a 3-year follow-up period.

Conclusions:

  • Fungal infections, such as cryptococcosis, can mimic lung metastasis in sarcoma patients.
  • Histopathological evaluation of lung lesions is essential to differentiate infection from metastasis.
  • Misdiagnosis can lead to inappropriate treatment, altering prognosis and patient outcomes.