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Published on: March 26, 2018

Timing of transcatheter aortic valve implantation in patients with aortic stenosis

Neil J Craig1, Bernard Prendergast2,3, David E Newby1

  • 1British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, United Kingdom.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|May 15, 2026
PubMed

Insights

The optimal timing for aortic valve replacement, especially transcatheter aortic valve implantation, is debated for severe aortic stenosis. Recent trials offer insights for clinical practice and guidelines.

Area of Science:

  • Cardiology
  • Valvular Heart Disease

Background:

  • Aortic stenosis is the most common valvular heart disease in Western countries, affecting over 12% of those aged 75+.
  • Debate exists on the optimal timing for aortic valve replacement, particularly for asymptomatic severe or symptomatic moderate aortic stenosis.

Purpose of the Study:

  • To review current evidence on the timing of aortic valve replacement, focusing on transcatheter aortic valve implantation (TAVI).
  • To discuss the impact of recent randomized controlled trials on clinical practice and guideline recommendations for aortic stenosis management.

Main Methods:

  • Review of current evidence on aortic valve replacement timing.
  • Focus on transcatheter aortic valve implantation (TAVI) evidence.
  • Analysis of recent randomized controlled trials.

Main Results:

  • Recent trials provide preliminary evidence for early intervention strategies in aortic stenosis.
  • Management of asymptomatic severe or symptomatic moderate aortic stenosis requires careful consideration of multiple factors.

Conclusions:

  • The optimal timing for aortic valve replacement in specific patient groups remains a key clinical question.
  • Recent trial data is influencing clinical practice and guideline development for aortic stenosis treatment.

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