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Updated: May 16, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
Published on: June 25, 2018
Synthesis of Carbamoylated Phenylalanine Derivatives and Peptide Modification via Palladium-Catalyzed Ex Situ CO
Anku Sharma1, Kamya Rao1, Gajanan K Rathod1
1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160 062, India.
Abstract:
A versatile palladium-catalyzed carbonylative coupling protocol for the synthesis of carbamoyl phenylalanine derivatives has been described. Using a two-chamber COware system, this strategy also enables the efficient conversion of iodo-group-containing peptides into diverse carbamoyl motifs within a fully assembled peptide sequence, including bioactive scaffolds. This work provides a versatile tool for rapidly generating modified peptide libraries via targeted side chain tailoring of the phenylalanine residue.
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