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Recent Advances in Natural Polymers-based Hydrogels for Periodontal Regeneration.
João de Freitas Gomes Neto1, Tainara de Paula de Lima Lima1, Luiza Meurer Brand2
1Graduate Program in Materials Science and Engineering, Federal University of São Carlos, São Carlos, SP, Brazil.
Macromolecular Bioscience
|May 15, 2026
Summary
Hydrogels made from natural polymers show promise for periodontal regeneration, aiding tissue repair and drug delivery. However, clinical translation faces challenges in standardization and regulatory approval.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Periodontal Research
Background:
- Periodontal diseases like periodontitis cause irreversible tissue loss and systemic issues.
- Current treatments offer limited true tissue regeneration.
- Hydrogels are explored as biomimetic matrices for periodontal tissue engineering.
Purpose of the Study:
- To review recent advances in natural polymer-based hydrogels for periodontal regeneration.
- To discuss the influence of hydrogel properties and processing on tissue regeneration.
- To examine hybrid platforms and advanced designs for periodontal applications.
Main Methods:
- Review of literature on hydrogels (alginate, collagen, chitosan, etc.) for periodontal regeneration.
- Analysis of polymer origin, crosslinking, properties, and processing (injectable, self-healing, 3D bioprinting).
- Examination of hybrid platforms (IPNs, composites) and controlled delivery systems (drugs, growth factors, exosomes, stem cells).
Main Results:
- Hydrogels modulate inflammation, deliver bioactive agents, and support periodontal tissues.
- Various hydrogel formulations demonstrate potential for cell adhesion, angiogenesis, and osteogenesis.
- Preclinical studies show coordinated regeneration of cementum, periodontal ligament, and alveolar bone.
Conclusions:
- Natural polymer hydrogels show significant preclinical promise for periodontal regeneration.
- Challenges remain in clinical trials, standardization, and regulatory pathways for translation.
