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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Preventing Both EBV Infection and EBV-Associated Diseases: Advances in Vaccine Research
Guo-Long Bu1,2, Li-Na Chen1, Pei-Huang Wu1
1State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
Abstract:
Epstein-Barr Virus (EBV), the first identified human oncovirus, is associated with a variety of human malignancies. It is estimated that more than 90% of the adults worldwide are infected with EBV. In 2020, EBV-attributable cancers accounted for approximately 1.3%-1.9% of the global cancer burden. Currently, no licensed vaccine against EBV is available for clinical use. The success of COVID-19 vaccines has provided a framework and momentum for novel efforts against EBV, accelerating vaccine research and yielding several promising candidates, some of which have entered clinical trials. These advances are expected to contribute substantially to preventing EBV infection and managing EBV-associated diseases. In this review, we assess the current landscape and recent advances in EBV vaccine research, summarizing progress across different vaccine platforms. This overview intends to provide a theoretical foundation for the future development and translational application of EBV vaccines.
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