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Bio-enhanced NGV/QC-Zn@ZSM-5 zeolite nanoplatform for stabilizing the dentin-adhesive interface
Guinong Qiao1, He Li1, Xuejian Liu1
1Department of Cariology, Endodontology and OperativeDentistry, School and Hospital of Stomatology, Jilin University, Changchun 130021, PR China; Jilin Provincial Key Laboratory of Science and Technology for Stomatology Nanoengineering, School and Hospital of Stomatology, Jilin University, Changchun 130021, PR China.
A novel nanoplatform combining quercetin, zinc, and NGV peptide enhances dentin adhesives. This improves collagen stability, bacterial inhibition, and remineralization, significantly boosting bonding durability for dental restorations.
Area of Science:
- Biomaterials Science
- Dental Materials
- Nanotechnology
Background:
- Long-term stability of resin-dentin interfaces in restorative dentistry is limited by collagen degradation and bacterial erosion.
- Synergistic antibacterial activity, collagen cross-linking, and remineralization are crucial for durable dentin bonding.
- Quercetin (QC) offers antibacterial and collagen cross-linking properties, enhanced by metal-phenolic networks (MPNs).
Purpose of the Study:
- To develop a bio-enhanced nanoplatform for dentin adhesives.
- To improve the stability and durability of the resin-dentin interface.
- To achieve synergistic antibacterial activity, collagen cross-linking, and remineralization.
Main Methods:
- Constructed a nanoplatform (NGV/QC-Zn@ZSM-5) using NGV peptide, quercetin-zinc MPN, and ZSM-5 zeolite.
- Incorporated Zn2+ into ZSM-5, coated with QC-Zn MPN, and functionalized with NGV.
- Utilized ZSM-5 for controlled Zn2+ release, collagen stabilization, and bacterial inhibition.
Main Results:
- The nanoplatform effectively stabilized collagen, inhibited bacterial biofilm formation, and promoted dentin remineralization.
- Modified adhesive showed a 2.03-fold increase in bond strength after aging compared to the control.
- The integrated strategy strengthened the resin-dentin interface against degradation, improving bonding durability.
Conclusions:
- The developed NGV/QC-Zn@ZSM-5 nanoplatform shows significant potential for enhancing dentin adhesives.
- This approach offers a promising strategy to improve the longevity and clinical performance of dental bonding restorations.
- The synergistic effects of the nanoplatform components address key limitations in current dental adhesive technology.
