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Updated: May 17, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Gut Microbiota and Venous Thromboembolism: An Emerging Link
Angela Di Giorgio1, Claudia Carnuccio1, Elina Verrilli1
1Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Angiology and Noninvasive Vascular Diagnostics Unit, Department of Cardiovascular Sciences CUORE, Italy.
The gut microbiota influences venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE). Microbial imbalances may increase VTE risk by promoting inflammation and endothelial dysfunction.
Area of Science:
- Microbiology
- Hematology
- Gastroenterology
Background:
- Venous thromboembolism (VTE) is a significant global health issue.
- The gut microbiota's role in systemic diseases is increasingly recognized.
- Thrombotic disorders may be influenced by gut microbial composition.
Purpose of the Study:
- To review current research on the gut microbiota's involvement in VTE pathogenesis.
- To explore the mechanisms by which gut dysbiosis contributes to thrombosis.
- To assess the potential of targeting the gut microbiota for VTE prevention.
Main Methods:
- Literature review of preclinical and clinical studies.
- Synthesis of evidence linking gut dysbiosis to VTE risk factors.
- Analysis of proposed molecular pathways.
Main Results:
- Gut dysbiosis is associated with systemic inflammation and endothelial dysfunction.
- Microbial metabolites and altered immune responses may promote a prothrombotic state.
- Evidence suggests the gut microbiota modulates coagulation pathways.
Conclusions:
- The gut microbiota plays a role in the development of VTE.
- Gut dysbiosis contributes to VTE pathogenesis through inflammation and endothelial dysfunction.
- Modulating the gut microbiota represents a potential novel strategy for VTE risk reduction.
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