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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
Published on: March 26, 2018
TAVR as a Viable Option for Patients with Pure Native Aortic Regurgitation
Jie Feng1, Yanrong Pi1, Kai Li1
1Nanchang University, The Second Affiliated Hospital, Jiangxi Medical College, Department of Cardiology, China.
The Thoracic and Cardiovascular Surgeon
|May 15, 2026
Summary
Transcatheter aortic valve replacement (TAVR) is now a viable treatment for pure aortic regurgitation (AR), offering a new option alongside surgical aortic valve replacement (SAVR). This analysis of clinical trials shows TAVR is safe and effective for AR patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Surgical aortic valve replacement (SAVR) is the standard for aortic regurgitation (AR).
- Transcatheter aortic valve replacement (TAVR) is increasingly used for high-risk patients.
- Recent Chinese expert consensus supports TAVR for pure AR, moving it beyond off-label use.
Purpose of the Study:
- To evaluate the efficacy and safety of transcatheter aortic valve replacement (TAVR) for pure aortic regurgitation (AR).
- To provide an updated analysis of clinical trial data on TAVR for AR treatment.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, EMBASE, OVID, Web of Science, Cochrane Library) up to March 28, 2024.
- Eligible clinical trial data were included for analysis.
- Study protocol registered with PROSPERO (CRD42024529532).
Main Results:
- Analysis included 21 studies with 5,978 patients.
- Device success rates were 74-100%; 0.35% required a second valve, 0.59% converted to SAVR.
- Thirty-day all-cause mortality was 4.6%; key secondary outcomes included MI (2.01%), stroke (1.84%), major bleeding (6.42%), and pacemaker implantation (6.72%).
Conclusions:
- Transfemoral TAVR is a beneficial treatment option for patients with aortic regurgitation (AR).
- TAVR represents a significant advancement in managing pure AR, offering a less invasive alternative.
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