Related Experiment Video
Updated: May 17, 2026

Tissue Processing and Isolation of Primary Fibroblasts from the Human Vagina
Published on: November 22, 2024
Vaginal aging: from concealed symptoms to defined biomarkers
Tong Wu1,2,3, Yibao Huang4,5,6, Rui Li7
1Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. tongwu66@tjh.tjmu.edu.cn.
Abstract:
Vaginal aging is a multifactorial biological process characterized by structural, functional, and molecular alterations driven primarily by estrogen decline. This review summarizes current evidence on potential biomarkers across five domains: physiological parameters, imaging features, histological changes, and molecular alterations. We further discuss methodological challenges and future research directions necessary to establish standardized and clinically applicable biomarkers. Understanding these biological indicators may facilitate earlier diagnosis, improve patient stratification, and enable personalized therapeutic interventions in women experiencing vaginal aging.
Related Concept Videos
The Effect of Aging on Tissues
Menopause
Disorders of the Female Reproductive System
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
