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Updated: May 18, 2026
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
Published on: April 28, 2015
Advances in Prussian blue nanoparticle-based anticancer platforms: synthesis, functionalization, and therapeutic
Chittathur Midhun Krishna1, Rupa Mazumder1, Rakhi Mishra2
1Department of Pharmaceutics, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India.
Introduction:
Cancer is a disease that has plagued human health throughout history. Prussian blue is a pigment that has been studied for its uses and approved also to be biologically safe for human use, and has been researched for anti-cancer activity. Prussian blue nanoparticles are a metal-organic framework (MOF) with photothermal, imaging properties that contribute towards the theranostics applications for cancer. They have also been found to possess excellent biocompatibility, immunomodulating properties, and enzyme-like activity, leading to exciting implications for their therapeutic potential.
Objective:
This review aims to serve as a concise and comprehensive overview of Prussian blue nanoparticles and their abilities against cancer with the discussion of the methods of synthesis and their mechanisms.
Methodology:
The presented data has been sourced from research articles published within the last 6 years, and the papers have been gathered from the sites PubMed, Google Scholar.
Conclusion:
The collected research presents Prussian blue nanoparticles as an excellent candidate against cancer. Research is ongoing to bring them to light and effectively apply them as a full-fledged anticancer agent, but as no clinical trials have been approved yet, translation remains a challenge. However, the future holds bright horizons as active research is underway.
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