Optimizing outcomes in keratolimbal allograft for limbal stem cell deficiency
Lokeshwari Aruljyothi1, Venugopal Anitha2, Keely Likosky3
1Department of Cornea and Refractive Services, Aravind Eye Hospital, Salem.
Purpose Of Review:
The present review will focus on recent advancements affecting outcomes in keratolimbal allograft (KLAL).
Recent Findings:
Recent advancements involve methodologies for donor selection, eye bank preparation of KLAL tissue, risk stratification, and immunosuppression to prevent both early and late immunologic rejection.
Summary:
Keratolimbal allograft (KLAL) remains an essential technique for addressing severe limbal stem cell deficiency in patients without access to a suitable living donor eye (whether autologous or allogeneic). While outcomes of KLAL have traditionally lagged behind those of living-related limbal allografts, recent advancement in KLAL techniques may reduce this gap.
