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Related Experiment Video

Updated: May 18, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Published on: June 23, 2023

Continuous Theta-Burst Stimulation Improves Long-Term Outcomes in Alcohol Use Disorder by Modulating a

Liang-Jie-Cheng Huang¹, Ning-Ning Zeng², Jing-Nan Zhao³

¹Department of Psychology, Ningbo University, Ningbo, China.

Biological Psychiatry

|May 16, 2026

Summary

This summary is machine-generated.

Continuous theta-burst stimulation (cTBS) significantly reduced drinking in alcohol use disorder (AUD) patients over 12 months. This circuit-based therapy shows promise for addiction by modulating neural networks involved in craving.

Keywords:

Alcohol use disorder Continuous theta-burst stimulation Craving Drinking reduction Functional connectivity Long-term efficacy

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Area of Science:

Neuroscience
Addiction Medicine
Psychiatry

Background:

Alcohol use disorder (AUD) is a chronic relapsing condition marked by craving.
Continuous theta-burst stimulation (cTBS) is a potential treatment for AUD, but its long-term effects and mechanisms require further investigation.

Purpose of the Study:

To evaluate the 12-month efficacy of right dorsolateral prefrontal cortex (DLPFC) cTBS for reducing alcohol consumption.
To identify neural and molecular mechanisms underlying cTBS treatment for AUD.

Main Methods:

Fifty-five alcohol-dependent patients received 20 sessions of active or sham cTBS over two weeks.
Clinical outcomes were assessed over 12 months, including drinking behavior and craving.
Functional MRI during a cue-reactivity task was used to investigate craving-related neuroplasticity.

Main Results:

Active cTBS significantly reduced the risk of returning to baseline or higher drinking levels compared to sham treatment over 12 months.
Significant improvements were observed in Alcohol Use Disorders Identification Test (AUDIT) scores and subjective craving.
Changes in a craving-related neural network, involving frontoparietal, subcortical, visual, and ventral attention systems, correlated with clinical improvements.

Conclusions:

cTBS demonstrates long-term clinical efficacy in reducing alcohol consumption for individuals with AUD.
The study identified a multiscale biomarker linked to synaptic transmission and myelination, offering insights into cTBS's therapeutic mechanisms.
cTBS presents a promising circuit-based therapy for addiction treatment.