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Updated: May 18, 2026

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
Association of Metabolic Dysfunction-Associated Steatohepatitis with Metabolic-Related Diseases: Diabetes,
Leonidas Diamantopoulos1, Markos Kalligeros2, Scott D Isaacs3
1Department of Medicine, Northwell Health/Staten Island University Hospital, New York City, NY, USA.
Abstract:
Metabolic dysfunction-associated steatohepatitis is a leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation, with the burden rising rapidly in people with type 2 diabetes, prediabetes, and obesity. In this mini-review, we summarize recent data on prevalence and regional disparities, and discuss key mechanisms including insulin resistance, lipotoxic injury, organelle stress, immune activation, and fibrogenic signaling. We review advances in noninvasive diagnostics, with emphasis on stepwise strategies using FIB-4 and noninvasive tests such as elastography. Finally, we address cardiovascular risk and systemic inequities that continue to delay diagnosis and limit access to care.
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