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Updated: May 18, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Currently Approved and Future Regimens for Metabolic Dysfunction-Associated Steatohepatitis
Eliabe S Abreu1, Mazen Noureddin2, Hirokazu Takahashi3
1Division of Gastroenterology & Hepatology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.
Abstract:
Metabolic dysfunction-associated steatohepatitis (MASH), the progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD), has historically been treated with lifestyle modification (dietary changes, exercise and weight loss). While lifestyle modification remains foundational in the treatment of MASLD/MASH, resmetirom (a thyroid hormone β-receptor agonist) and semaglutide (a glucagon-like-peptide-1 receptor agonist) are now Food and Drug Administration-approved for patients with MASH and clinically significant hepatic fibrosis (ie, F2-F3 fibrosis). Emerging therapies will allow for future opportunities at a personalized approach to treatment of MASH. This article reviews currently approved and future regimens for the treatment of MASH and MASH-related cirrhosis.
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