Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bioinspired Adaptive UV-NIR Cross-Band Convolutional Fusion for Motion and Shape Recognition in Adverse Environments.

The journal of physical chemistry letters·2026

Same author

Neural Activity Alterations and Their Association With Neurotransmitter and Genetic Profiles in Schizophrenia: Evidence From Clinical Patients and Unaffected Relatives.

CNS neuroscience & therapeutics·2025

Same author

Gut proinflammatory bacteria is associated with abnormal functional connectivity of hippocampus in unmedicated patients with major depressive disorder.

Translational psychiatry·2024

Same author

Artificial Retina Based on Organic Heterojunction Transistors for Mobile Recognition.

Nano letters·2024

Same author

Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging combined with Texture Analysis in Predicting the Histological Grades of Rectal Adenocarcinoma.

Current medical imaging·2024

Same author

Meta-analysis of cortical thickness reduction in adult schizophrenia.

Journal of psychiatry & neuroscience : JPN·2023

Search research articles

Related Experiment Video

Updated: May 19, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Brain structure and function changes in Crohn's disease with or without depression based on multi-modal MRI.

Yilin Guan¹, Xiang Peng², Xueting Wu²

¹Department of Radiology, The Six Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China; Department of Radiology, Jiangmen Centrol Hospital, Jiangmen, 529000, China.

Journal of Affective Disorders

|May 17, 2026

Summary

Crohn

Keywords:

Crohn's disease Depression Functional connectivity Resting-state fMRI Voxel-based morphometry

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Related Experiment Videos

Last Updated: May 19, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Area of Science:

Neuroscience
Gastroenterology
Psychiatry

Background:

Crohn's disease (CD) frequently co-occurs with depression.
Neural mechanisms linking CD and depression are not well understood.

Purpose of the Study:

Investigate brain structural and functional changes in CD patients.
Examine the relationship between these changes, depressive symptoms, inflammation, and disease activity.

Main Methods:

Used resting-state functional MRI and structural MRI on 70 CD patients and 60 controls.
Assessed depression using PHQ-9 and HAMD-24.
Analyzed gray matter volume (GMV) differences and functional connectivity (FC).

Main Results:

CD patients showed reduced cerebellar lobule 8 GMV, linked to inflammation.
Observed decreased FC between cerebellum and sensorimotor, frontoparietal, and default mode networks.
Brain changes were not directly correlated with depression severity in CD groups.

Conclusions:

Crohn's disease involves inflammation-related brain alterations.
These changes correlate with disease activity and depressive symptoms.
Depression in CD may stem from inflammation-driven gut-brain axis changes.