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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

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Related Experiment Video

Updated: May 19, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Targeting Metabolism in Cancer Therapy: Inhibitors and Approaches.

Bhabani Shankar Nayak1, Bangmayee Dash2, Sisir Nandi3

  • 1KIIT School of Pharmacy, KIMS, KIIT DEEMED to be University, Bhubaneswar, Odisha, India.

Cancer Treatment and Research
|May 17, 2026
PubMed
Summary
This summary is machine-generated.

Targeting abnormal cancer cell metabolism offers a novel therapeutic strategy. Inhibiting key pathways like glycolysis and fatty acid synthesis shows promise in cancer treatment and management.

Keywords:
Cancer metabolismGlutaminase inhibitorsGlycolytic inhibitorsMitochondrial inhibitorsPPP inhibitors

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Assessment of the Metabolic Profile of Primary Leukemia Cells
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Assessment of the Metabolic Profile of Primary Leukemia Cells

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Last Updated: May 19, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Area of Science:

  • Oncology
  • Metabolic pathways
  • Cancer biology

Background:

  • Cancer cells exhibit altered metabolic pathways crucial for their growth and survival.
  • Metabolic reprogramming is a hallmark of cancer, supporting tumor formation and providing therapeutic vulnerabilities.
  • Historical research, including Otto Warburg's work on aerobic glycolysis, laid the foundation for understanding cancer metabolism.

Purpose of the Study:

  • To explore novel therapeutic strategies targeting cancer cell metabolism.
  • To investigate the efficacy of inhibiting major metabolic pathways in cancer treatment.
  • To highlight the role of metabolic reprogramming in neoplastic cell treatment.

Main Methods:

  • Inhibition of key metabolic pathways including glycolysis, pentose phosphate pathway (PPP), fatty acid synthesis, and mitochondrial metabolism.
  • Utilizing metabolic liabilities for cancer treatment.
  • Combination therapy with chemotherapies.
  • Preclinical models for evaluating metabolic targeting agents.
  • Application of multi-omics, single-cell, and spatial technologies for metabolic tracking.

Main Results:

  • Inhibiting major metabolic pathways demonstrates efficacy in treating neoplastic cells.
  • Metabolic reprogramming combined with chemotherapy is a successful approach for cancer management.
  • Metabolic molecules targeting nucleic acid synthesis and other biochemical processes are under investigation.
  • Advanced technologies enable accurate tracking of cancer metabolism.

Conclusions:

  • Targeting cancer cell metabolism represents a promising and emerging therapeutic approach.
  • Metabolic reprogramming is a viable strategy for cancer treatment and management.
  • Continued research and technological advancements are crucial for refining metabolic therapies.