Short-Term Visual and Optical Performance of the ZEISS CT LUCIA 621P Intraocular Lens Across Different Power Ranges

To evaluate the short-term efficacy and optical performance of the ZEISS CT LUCIA 621P intraocular lens (IOL) in cataract patients using a diopter (D)-stratified approach.

This retrospective study included 304 eyes of 216 patients who underwent phacoemulsification with CT LUCIA 621P implantation. Eyes were stratified into four groups by implanted IOL power: Group 1 (<20.0 D, n=49), Group 2 (20.0-21.5 D, n=137), Group 3 (22.0-23.5 D, n=60), and Group 4 (≥24.0 D, n=58). Primary outcomes were monocular and binocular photopic/mesopic defocus curves and internal higher-order aberrations (HOAs) at 1 and 3 months because these directly evaluate the optical quality and depth of focus delivered by the non-constant aspheric ZEISS Optic design-the core innovative feature of the CT LUCIA 621P IOL-across the full spectrum of implanted powers. Secondary outcomes provide complementary clinical efficacy data; uncorrected and corrected distance visual acuity (UDVA/CDVA), uncorrected intermediate (UIVA) and near (UNVA), refractive predictability, and contrast sensitivity (CS). Analyses used generalized estimating equations (GEE) with an exchangeable correlation structure.

All groups achieved excellent refractive predictability with convergence of spherical equivalent (SE) toward emmetropia (p=0.398). Mean monocular UDVA at 3 months was comparable across groups (p=0.498). Monocular and binocular UIVA and UNVA were also comparable (all p>0.23). Photopic and mesopic defocus curves showed similar depth of focus across groups (p>0.05 at most levels). Postoperative spherical aberration (SA) and coma remained low with no significant inter-group differences after generalized GEE adjustment (p>0.17). Photopic CS was comparable across IOL power groups at most spatial frequencies.

The CT LUCIA 621P IOL demonstrated consistent refractive predictability, VA across distances, and optical quality across a wide range of implanted powers, supporting its reliable use in contemporary cataract surgery.