Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ionic Crystal Structures02:42

Ionic Crystal Structures

Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
Common Ion Effect03:24

Common Ion Effect

Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rigid and electrode-compatible multicomponent organic crystals for piezoelectric energy harvesting.

Journal of materials chemistry. A·2026
Same author

Manganese-Templated Nontrivial Structures for MRI and Therapy.

Journal of the American Chemical Society·2026
Same author

ZIF-8 as Potential Pesticide Adsorbent Medium for Wastewater Treatment: The Case Study of Model Linuron Extraction Conditions Optimization via Design of Experiment.

Molecules (Basel, Switzerland)·2025
Same author

Targeted Delivery of Lidocaine in Breast Cancer Cells via Zeolitic Imidazolate Framework-8 Nanoparticles.

Chemphyschem : a European journal of chemical physics and physical chemistry·2025
Same author

Solvent Effects in Biomass-Derived Activated Carbons: New Insights for Their Doping/Functionalization toward Potential Hydrogen Storage Applications.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

The Use of Deep Eutectic Solvents for the Synthesis of Iron Oxides Nanoparticles: A Driving Force for Materials Properties.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same journal

Impact of an Artificial Albumin Corona on Surface Charge-Driven Nano-Bio Interactions and Cytotoxicity of Silver Nanoparticles.

ACS omega·2026
Same journal

Structural and Functional Disruption of Thiopurine S‑Methyltransferase by the A80P Variant: A Simulation and Genotyping Study.

ACS omega·2026
Same journal

CRISPR/Cas12a2-Mediated Ultrasensitive Assay for Rapid Detection of H1N1 Influenza Virus RNA.

ACS omega·2026
Same journal

Photocatalytic Treatment of Real Sugar Industry Wastewater Using Lignocellulosic Biomass-Derived Hydrochar/g-CN.

ACS omega·2026
Same journal

Electrochemical Dopamine Biosensor Based on Plant-Derived Peroxidase Immobilized on Titanate Nanowires.

ACS omega·2026
Same journal

Revealing the Effects of Process Parameters on Structural, Thermal, Mechanical, Biodegradation, and Biocompatibility Properties on the Electrospinning of Poly(vinyl alcohol)/Microbial Inulin Nanofibers.

ACS omega·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles
04:53

Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles

Published on: May 26, 2023

An Mg Solid Solution Affords a Less Toxic and More Stable ZIF‑8.

Nicola di Nicola1, Enrico Spoletti2, Pierre Cezade2

  • 1Department of Physical and Chemical Sciences, University of L'Aquila, via Vetoio (Coppito 2), L'Aquila 67100, Italy.

ACS Omega
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a mixed-metal ZIF-8 analogue using zinc and magnesium, enhancing stability for drug delivery applications. The new material reduces zinc content and improves performance under acidic conditions.

More Related Videos

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes
07:45

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes

Published on: August 16, 2018

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria
08:24

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria

Published on: September 20, 2024

Related Experiment Videos

Last Updated: May 19, 2026

Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles
04:53

Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles

Published on: May 26, 2023

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes
07:45

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes

Published on: August 16, 2018

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria
08:24

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria

Published on: September 20, 2024

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Porous coordination polymers (PCPs) and metal-organic frameworks (MOFs) are explored for drug delivery.
  • ZIF-8, a common MOF, faces challenges due to high zinc content and limited stability in acidic environments.
  • Biocompatibility and physiological stability are crucial for MOF-based drug delivery systems.

Purpose of the Study:

  • To develop a modified ZIF-8 with improved stability and reduced zinc content for safer drug delivery.
  • To investigate the effect of incorporating magnesium into the ZIF-8 structure.
  • To understand the relationship between composition, stability, and potential drug delivery applications.

Main Methods:

  • Synthesis of a mixed-metal ZIF-8 analogue incorporating Zn2+ and Mg2+.
  • Characterization of the solid solution's structural and chemical properties.
  • Assessment of water stability under mildly acidic conditions.
  • Density Functional Theory (DFT) calculations to elucidate stability mechanisms.

Main Results:

  • A mixed-metal ZIF-8 analogue was successfully synthesized with up to 20% magnesium substitution.
  • The resulting solid solution exhibited enhanced water stability under mildly acidic conditions compared to pure ZIF-8.
  • DFT calculations suggested reduced polarizability contributes to the improved stability.
  • Stability improvements were observed across a range of Zn/Mg ratios, not strictly correlating with composition changes.

Conclusions:

  • Mixed-metal ZIF-8 analogues offer a promising strategy to mitigate concerns associated with pure ZIF-8 for drug delivery.
  • The incorporation of magnesium enhances the stability of ZIF-8, potentially broadening its applicability in physiological conditions.
  • Further research is needed to fully correlate composition with stability modulation for optimized drug delivery performance.