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Updated: May 19, 2026

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation
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Biofabricated Alginate Hydrogels to Study Prostate Tumoral Microenvironments In Vitro.

Khalsa Al-Husaini1,2, Eugenia Spessot3, Esther Baena4

  • 1Division of Pharmacy and Optometry, Medicine and Health, The University of Manchester, M13 9PL Manchester, U.K.

ACS Omega
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

Engineered 3D bioprinted models mimic prostate cancer

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Published on: September 22, 2023

Area of Science:

  • Biomaterials Science
  • Cancer Biology
  • Tissue Engineering

Background:

  • The tumor microenvironment (TME) is crucial for cancer progression.
  • Engineered 3D in vitro models are vital for studying TME and cancer cell-material interactions.
  • Prostate cancer (PCa) progression involves complex biomechanical and biochemical changes.

Purpose of the Study:

  • To develop a prostate-specific 3D bioprinted model.
  • To mimic the biomechanical (stiffness) and biochemical (laminin-enriched) properties of the PCa extracellular matrix (ECM).
  • To investigate the impact of matrix properties on PCa cell behavior.

Main Methods:

  • Synthesized functionalized alginate hydrogels with laminin-mimetic peptides.
  • Tuned hydrogel stiffness (2-20 kPa) to represent healthy to metastatic PCa.
  • Utilized extrusion-based bioprinting to create 3D models with PC-3 cells and cancer-associated fibroblasts (CAFs).

Main Results:

  • Bioprinted models supported high PC-3 cell viability and proliferation.
  • Stiffer, laminin-enriched matrices upregulated CD44 and vimentin expression in PC-3 cells.
  • Matrix-driven effects on PCa cells were observed independently of CAFs.

Conclusions:

  • Established a robust biofabrication strategy for TME-mimetic models.
  • Developed a valuable tool for screening TME-targeting therapies.
  • Provided insights into the mechanobiology of PCa progression.