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Updated: May 19, 2026
Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Research on paclitaxel in chemotherapy-induced neuropathic pain: a bibliometric analysis integrating multiple
Rui Zeng1,2, Min Xue3, Mingxia Pan4
1Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Background:
Paclitaxel-induced peripheral neuropathy (PIPN) significantly impairs the quality of life of cancer survivors. A systematic visualization of global research trends in this domain is currently lacking.
Objective:
This study aims to delineate the global research landscape, emerging hotspots, and evolutionary trends of PIPN research from 2000 to 2025.
Methods:
Relevant literature was retrieved from Web of Science Core Collection and Scopus. Bibliometric analyses, including co-occurrence and thematic evolution, were performed using VOSviewer and CiteSpace.
Results:
A total of 1,795 eligible publications were analyzed, exhibiting an exponential growth trend (R 2 = 0.9675R 2 = 0.9675). The United States led with 718 publications and the highest citation impact. Supportive Care in Cancer was the most prolific journal. Research focus has shifted from initial toxicity descriptions to underlying mechanisms (e.g., oxidative stress) and quality of life. Cluster analysis identified emerging interests in "anxiety" and psychosocial comorbidities.
Conclusion:
PIPN research is rapidly expanding, moving from phenomenological observation to mechanistic elucidation and holistic management. Future directions include precision medicine and comprehensive biopsychosocial interventions.
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