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Updated: May 19, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

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Published on: June 8, 2022

Decoding the S1P-S1PR axis in cancer: Mechanisms, pathways and therapeutic horizons (Review)

Yun-Ta Chuang1,2, I-Hui Wu3, Cheng-Fan Lee2

  • 1School of Medicine, University of Lancashire, Preston, Lancashire PR1 2HE, UK.

Biomedical Reports
|May 18, 2026
PubMed
Summary

Sphingosine-1-phosphate (S1P) signaling in cancer involves reprogramming of its receptors (S1PRs). Targeting both S1P production and S1PR signaling offers precise, biomarker-informed cancer therapies.

Keywords:
cancer progressionsphingosine-1-phosphatesphingosine-1-phosphate receptorsphingosine-1-phosphate-targeted therapytumor microenvironment

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