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Indigo Carmine Visualization Duration in Urine: A Randomized Kinetics Study.

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Summary
This summary is machine-generated.

Indigo carmine has a short plasma half-life of 12 minutes and is rapidly excreted in urine, causing temporary blue discoloration. This supports its use in surgical procedures for visualizing urinary tract function.

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Area of Science:

  • Pharmacology
  • Urology
  • Clinical Trials

Background:

  • Indigo carmine is frequently used for visualizing ureteral efflux during surgery.
  • Limited data exist on indigo carmine pharmacokinetics and urine color duration.
  • Understanding persistence aids accurate intraoperative urinary system assessment.

Purpose of the Study:

  • To observe plasma and urinary pharmacokinetics of indigo carmine in healthy volunteers.
  • To determine the duration of blue color in voided urine after indigo carmine administration.

Main Methods:

  • Open-label, randomized clinical trial with 16 healthy participants.
  • Intravenous injection of either 2.5-mL or 5.0-mL indigo carmine.
  • Collection of blood and urine samples at various time points post-injection; stool collection.

Main Results:

  • Plasma concentration peaked within 5 minutes, with elimination below quantification by 2 hours.
  • Estimated plasma half-life of indigo carmine was 12 minutes.
  • Urine discoloration persisted up to 6 hours in 10/16 participants and 12 hours in 1/16.

Conclusions:

  • Short half-life and rapid urinary excretion support indigo carmine's clinical utility.
  • Findings align with the typical time to ureteral efflux observed during surgery.
  • Supports its use for intraoperative cystoscopy and urinary tract assessment.