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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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COMMD3 mediates melanin synthesis through both clusterin-PAX3 axis and copper-dependent tyrosinase activity in skin

Xinyi Huang1, Shan Wu1, Min Yan2

  • 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal of Dermatological Science
|May 18, 2026
PubMed
Abstract

Keywords:
COMMD3ClusterinMelanogenesisPAX3Skin pigmentationTyrosinase activity

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