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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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Related Experiment Video

Updated: May 20, 2026

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
04:43

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation

Published on: May 23, 2025

Does Earlier Laser Intervention for Post-Surgery Scars Yield Superior Outcomes?

Hua-Wei Ouyang1, Yi Zou2, Yi-Pan Liu2

  • 1Department of Plastic and Laser Cosmetic, Hunan Provincial People's Hospital (1st Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China. ouyanghuawei@yeah.net.

Aesthetic Plastic Surgery
|May 18, 2026
PubMed
Summary

CO2 fractional laser treatment significantly reduces scar formation in rabbit ears. Early intervention within one month post-surgery does not offer superior scar reduction compared to later treatment.

Keywords:
CO2 fractional laserRabbit ear incisionScar

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Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
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Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

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Apparatus for Harvesting Tissue Microcolumns
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Apparatus for Harvesting Tissue Microcolumns

Published on: October 25, 2018

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Last Updated: May 20, 2026

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Published on: May 23, 2025

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Apparatus for Harvesting Tissue Microcolumns
06:06

Apparatus for Harvesting Tissue Microcolumns

Published on: October 25, 2018

Area of Science:

  • Dermatology
  • Laser Surgery
  • Wound Healing

Background:

  • Scar formation is a common concern following surgical procedures.
  • Optimizing the timing of interventions like CO2 fractional laser therapy is crucial for effective scar management.

Purpose of the Study:

  • To evaluate the efficacy of CO2 fractional laser intervention at different time points post-surgery on scar formation.
  • To guide clinical practice in determining the optimal timing for laser scar treatment.

Main Methods:

  • Six groups of New Zealand white rabbits underwent surgical incisions and received CO2 fractional laser treatment at varying intervals (day of surgery to 4 weeks post-surgery).
  • Scar Cosmesis Assessment and Rating (SCAR) scores, dermal thickness (HE staining), collagen volume fraction (Masson staining), and microvascular density (CD31 immunohistochemistry) were assessed at 7 weeks post-surgery.
  • Statistical analysis included one-way ANOVA and LSD post hoc tests (P < 0.05).

Main Results:

  • All laser-treated groups (day of surgery to 4 weeks post-surgery) showed significantly reduced scar formation compared to the non-laser control group.
  • Macroscopic observations and SCAR scores indicated less pronounced scarring in laser-treated groups.
  • No statistically significant differences in scar parameters were found among the different laser intervention timing groups (P > 0.05).

Conclusions:

  • CO2 fractional laser intervention is effective in reducing scar formation when applied within one month post-surgery.
  • The timing of CO2 fractional laser treatment within the first month does not significantly impact the final scar outcome.