Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diversity in Cell Signaling Responses

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Chromatin Modification in iPS Cells

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...

Gene-Environment Interactions

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Toward Precision Electrochemical Sensing of CFTR Function in Cystic Fibrosis Models.

Analytical chemistry·2026

Same author

MethPy: a new software for analyzing non-CpG methylation after bisulfite assay and Sanger sequencing.

Scientific reports·2025

Same author

Development of a <sup>1</sup>H qNMR method for the identification and quantification of monosaccharides in dietary fibre fractions.

Communications chemistry·2025

Same author

One-carbon metabolism modulates miR-29a-DNA methylation crosstalk in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Same author

Oxidative stress - Alzheimer's disease - DNA methylation: the role of arsenic.

Essays in biochemistry·2025

Same author

The epigenetic potential of vitamin K2 in brain health.

Epigenomics·2025

Search research articles

Related Experiment Video

Updated: May 20, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

Epigenetics in Space: The Dynamic Cellular Response.

Andrea Fuso^1,2

¹Deptartment of Experimental Medicine, Sapienza University of Rome, V.le Regina Elena 324, 00161,, Rome, Italy. andrea.fuso@uniroma1.it.

Methods in Molecular Biology (Clifton, N.J.)

|May 18, 2026

Summary

This summary is machine-generated.

Space colonization requires understanding health risks. Epigenetic modifications, influenced by space

Keywords:

Chromatin remodeling DNA methylation Epigenetics Histone modifications MicroRNAs

More Related Videos

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

Related Experiment Videos

Last Updated: May 20, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

Area of Science:

Space biology
Molecular biology
Human health in space

Background:

Space colonization presents new human health challenges.
Altered gravity and space environments induce cellular stress and alter gene expression.
Epigenetic modifications, crucial for gene regulation and stress response, are understudied in space.

Purpose of the Study:

To explore the role of epigenetic modifications in cellular responses to space environments.
To highlight the interaction between environment, epigenome, and cell function.
To review current knowledge and techniques for studying space-induced epigenetic changes.

Main Methods:

Review of existing literature on spaceflight effects on epigenetics.
Discussion of epigenetic mechanisms including DNA methylation, histone modifications, and non-coding RNAs.
Consideration of challenges and alternative methods (simulated microgravity) for studying labile epigenetic marks.

Main Results:

Epigenetic modifications mediate cellular responses to space stimuli.
The environment-epigenome-cell interaction is linked to dyshomeostasis and disease.
DNA methylation is a key epigenetic mark affected by space, but difficult to study in situ.

Conclusions:

Comprehensive epigenetic studies are crucial for understanding space colonization health risks.
Investigating epigenetic changes is vital for astronaut health and long-term space missions.
Simulated microgravity offers a viable approach for studying labile epigenetic modifications on Earth.