Related Experiment Video

Updated: May 20, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Natriuretic Peptides as a Biomarker of Cognitive Decline in Hypertension

Giovanna Gallo1,2, Gianmarco Dutti1,2,3, Maurizio Volterrani3

  • 1Department of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa, Rome, 1035-1039, 00189, Italy.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|May 18, 2026
PubMed

Insights

Natriuretic peptides (NPs) may serve as early biomarkers for cognitive decline in hypertension patients. This review explores their potential for early detection and management of hypertension-related cognitive impairment.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Biomarkers

Background:

  • Cognitive decline and dementia are common outcomes of atherosclerosis and hypertension.
  • Hypertension guidelines now recognize cognitive decline as a key therapeutic target.
  • Early detection of cognitive decline is challenging due to varied clinical presentations.

Purpose of the Study:

  • To review and update evidence on natriuretic peptides (NPs) as biomarkers for cognitive decline.
  • To examine the role of NPs in the context of hypertension.
  • To identify potential future clinical applications of NPs in diagnosis and treatment.

Main Methods:

  • Literature review and evidence synthesis.
  • Analysis of studies investigating the link between NPs, cognitive function, and hypertension.
  • Exploration of diagnostic and therapeutic potential.

Main Results:

  • Evidence suggests a link between natriuretic peptides (NPs) and cognitive function in hypertensive individuals.
  • NPs show potential as early indicators of cognitive impairment.
  • Further research is needed to establish clinical utility.

Conclusions:

  • Natriuretic peptides (NPs) represent a promising avenue for biomarker development in hypertension-related cognitive decline.
  • Clinical applications may include early diagnosis, severity assessment, and treatment monitoring.
  • Future studies should focus on validating NPs in diverse clinical settings.

Keywords:
Cognitive declineDementiaHypertensionHypertension mediated organ damageNatriuretic peptidesRehabilitation

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