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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Gallstones in the Metabolic Syndrome Era: Findings from a Case-Control Study
Muhammad Hasan Masood1,2, Muhammad Aamir Jameel1,2, Khalid Masood Gondal3
1Department of General Surgery and Surgical Oncology, Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan.
Summary
Obesity is strongly linked to gallstones (cholelithiasis). Metabolic syndrome (MetS) also shows associations, particularly in younger adults and females, suggesting complex relationships.
Area of Science:
- General Surgery
- Internal Medicine
- Public Health
Background:
- Cholelithiasis (gallstones) is a common condition.
- Metabolic syndrome (MetS) is a cluster of conditions increasing heart disease and diabetes risk.
- Understanding the link between MetS and cholelithiasis is crucial for prevention and management.
Purpose of the Study:
- To investigate the association between metabolic syndrome (MetS) and its components with cholelithiasis.
- To identify specific components of MetS that contribute to gallstone formation.
Main Methods:
- A case-control study was conducted with 120 adult participants (60 cases with cholelithiasis, 60 controls).
- Metabolic syndrome was defined using NCEP-ATP III criteria.
- Logistic regression and chi-square tests were used to analyze associations, with stratification for age and gender.
Main Results:
- Obesity was independently associated with cholelithiasis (OR: 4.016, p=0.001).
- Metabolic syndrome was more frequent in cases aged <45 years (p=0.036) and in female cases (p=0.048).
- Higher prevalence of obesity and MetS was observed in the cholelithiasis group compared to controls.
Conclusions:
- Obesity is a significant independent risk factor for cholelithiasis.
- Metabolic syndrome shows specific associations with gallstones in younger adults and females.
- These findings highlight the importance of managing obesity and MetS components for gallstone prevention.
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