Predictive value of EASIX for CKD patients with CRS

Area of Science:

• Cardiology
• Nephrology
• Biomarkers

Background:

• Cardiorenal syndrome (CRS) is a complex condition involving heart and kidney dysfunction.
• Endothelial activation plays a crucial role in the pathophysiology of CRS.
• Identifying reliable biomarkers for early detection and risk stratification in CRS is essential.

Purpose of the Study:

• To investigate the predictive value of endothelial activation, specifically the endothelial activation and stress index (EASIX), for CRS in patients with chronic kidney disease (CKD).
• To compare the predictive performance of EASIX against other factors like red cell distribution width (RDW) and CKD stage.

Main Methods:

• A retrospective study involving 253 CKD patients, divided into CRS (n=77) and non-CRS (n=176) groups.
• Univariate and binary logistic regression analyses were used to identify influencing factors.
• Receiver operating characteristic (ROC) curve analysis evaluated the predictive value of EASIX, RDW, and CKD stage.

Main Results:

• Significant differences were observed between groups in hypertension, RDW, blood urea nitrogen, albumin, interleukin-6, C-reactive protein, EASIX, and CKD stage (P < .05).
• RDW, EASIX, and CKD stage were identified as independent influencing factors for CRS in CKD patients (P < .05).
• EASIX showed a high predictive value (AUC = 0.821), outperforming RDW (AUC = 0.742) and CKD stage (AUC = 0.737). Post-treatment, lower EASIX scores correlated with better calcium and phosphorus levels.

Conclusions:

• EASIX demonstrates significant predictive value for identifying CKD patients with CRS.
• The findings suggest EASIX can serve as a valuable evaluation index for risk stratification and management in this patient population.
• Further research could explore EASIX's role in guiding therapeutic interventions for CRS.