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The Role of suPAR in Kidney Injury Progression
Hong Guo1, Jincai Yang1, Qiaoyun Ye2
1Department of Critical Care Medicine/MICU, Gansu Provincial Maternity and Child-care Hospital/ Gansu Provincial Central Hospital, Lanzhou, Gansu, 730000, China.
Current Molecular Medicine
|May 19, 2026
Summary
Soluble urokinase plasminogen activator receptor (suPAR) drives kidney injury by promoting inflammation and oxidative stress in acute kidney injury (AKI) and fibrosis in chronic kidney disease (CKD), facilitating AKI-to-CKD transition.
Area of Science:
- Nephrology
- Pathophysiology
- Biomarkers
Background:
- Kidney injury encompasses acute kidney injury (AKI) and chronic kidney disease (CKD).
- Soluble urokinase plasminogen activator receptor (suPAR) is implicated in various pathophysiological processes.
- Understanding suPAR's role is crucial for improving kidney disease management.
Purpose of the Study:
- To review the influence of suPAR on kidney injury.
- To clarify the mechanisms by which suPAR affects kidney health.
- To inform treatment strategies and enhance patient outcomes.
Main Methods:
- Comprehensive literature review of research articles, meta-analyses, and clinical studies.
- Analysis of suPAR's structure, function, and role in kidney injury.
- Exploration of mechanisms using in vitro, animal, and human studies focusing on inflammation, oxidative stress, apoptosis, and fibrosis.
Main Results:
- suPAR promotes AKI progression through inflammation, oxidative stress, and apoptosis.
- In CKD, suPAR induces podocyte injury and renal fibrosis.
- Elevated suPAR levels predict AKI incidence and CKD progression, mediating AKI-to-CKD transition.
Conclusions:
- suPAR is a key pathogenic mediator in kidney injury.
- It drives progression in AKI and CKD via distinct mechanisms.
- suPAR is a critical factor and biomarker facilitating the transition from AKI to CKD.
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