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Updated: May 20, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals
Renzhe Li1, Chang Liu1, Wenyuan Li1
1Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, United States.
Abstract:
Radicals with intrinsic stereogenic and radical centers offer a promising yet largely unexplored platform for synthetic chemistry. We reported a family of chiral sulfonimidoyl radicals that enable stereoretentive radical transfer by using our bench-stable reagents. This approach unlocked switchable, modular access to enantioenriched sulfoximines or sulfinamides, avoiding the use of strong oxidants and organometallic nucleophiles. Additionally, mechanistic studies and computational investigations provide insightful and plausible explanations for the observed high fidelity of these underexplored chiral sulfonimidoyl radical species.
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